Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.628


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2



Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_95794416 2.589 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr18_-_56190980 1.983 NM_005912
MC4R
melanocortin 4 receptor
chr10_+_114033403 1.961 NM_058222
TECTB
tectorin beta
chr4_+_77575276 1.959 NM_020859
SHROOM3
shroom family member 3
chr7_+_89681069 1.911 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr10_-_73518772 1.823 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr10_+_77212524 1.767 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr12_-_10846435 1.716 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr12_-_66839589 1.679 NM_000619
IFNG
interferon, gamma
chr7_+_29486010 1.676 NM_001039936
CHN2
chimerin (chimaerin) 2
chr1_-_150328153 1.657 NM_001008536
TCHHL1
trichohyalin-like 1
chr3_-_156904690 1.565 NM_014996
PLCH1
phospholipase C, eta 1
chr9_-_4142182 1.544 NM_152629
GLIS3
GLIS family zinc finger 3
chr4_+_185063421 1.519 NM_020225
STOX2
storkhead box 2
chr3_-_42280442 1.455 NM_001174138
CCK
cholecystokinin
chr1_-_155936904 1.352 NM_052939
FCRL3
Fc receptor-like 3
chr13_-_27441290 1.335 NM_001265
CDX2
caudal type homeobox 2
chr2_+_204509698 1.315 NM_012092
ICOS
inducible T-cell co-stimulator
chr17_-_25685175 1.274 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr17_+_57811645 1.222 NM_173503
EFCAB3
EF-hand calcium binding domain 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 13 of 13 entries
Enrichment   P-value GO Accession GO Term
58.23 1.29e-04 GO:0060338 regulation of type I interferon-mediated signaling pathway
35.23 5.65e-05 GO:0001959 regulation of cytokine-mediated signaling pathway
34.67 6.12e-05 GO:0060759 regulation of response to cytokine stimulus
28.19 2.49e-03 GO:0060337 type I interferon-mediated signaling pathway
28.19 2.49e-03 GO:0071357 cellular response to type I interferon
27.74 2.66e-03 GO:0034340 response to type I interferon
14.20 5.10e-03 GO:0009615 response to virus
12.94 7.97e-03 GO:0045088 regulation of innate immune response
11.89 1.20e-02 GO:0019221 cytokine-mediated signaling pathway
10.73 1.95e-02 GO:0071345 cellular response to cytokine stimulus
9.28 7.90e-03 GO:0034097 response to cytokine stimulus
6.92 4.03e-02 GO:0051707 response to other organism
2.05 1.57e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 2 of 2 entries
Enrichment   P-value GO Accession GO Term
4.66 1.11e-02 GO:0005615 extracellular space
4.50 2.00e-03 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
Enrichment   P-value GO Accession GO Term
11.82 2.63e-03 GO:0005126 cytokine receptor binding
10.99 3.72e-03 GO:0005125 cytokine activity